MATLAB is one of the most popular prototyping systems available in research computing. It is a set of powerful tools all wrapped in a language similar to FORTRAN with object oriented features.
XSEDE is a set of national computing resources that researcher can apply for. It is one in a set of national resources that powers a large share of national resources including DOE, Blue Waters, and others.
Currently it is very difficult to combine the two sets of resources. MATLAB is commercial and getting access to a license that you can use on XSEDE can be problematic due to license cost and technical complexity.